Drugs

Imuran

Generic Name: Azathioprine
Product Name: Imuran

Indication of Imuran:

Azathioprine is used for the following indications:Immunosuppression in:
  • Severe rheumatoid arthritis.
  • Systemic lupus erythematosus.
  • Dermatomyositis and polymyositis.
  • Autoimmune chronic active hepatitis.
  • Pemphigus vulgaris.
  • Polyarteritis nodosa.
  • Autoimmune haemolytic anaemia.
  • Autoimmune thrombocytopenic purpura.
  • Prevention of organ transplant rejection.
  • Inflammatory Bowel Disease.
  • Behcet's syndrome.

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    Action of Imuran:

    Azathioprine suppresses the immune system and reduces inflammation.

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    Dose advice of Imuran:

  • The hematologic response should be monitored to guide dosing. Bone marrow suppression will limit the dose that can be given.
  • The initial recommended dose is 2-3 mg/kg once daily given either orally or intravenously.
  • Maintenance dosing is 1-3 mg/kg or the minimum dose required to control the disease or prevent transplant rejection.
  • Renal impairment: Dose reductions may be necessary.
  • Hepatic impairment: Dose reductions may be necessary.

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    Schedule of Imuran:

    S4

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    Common side effects of Imuran:

  • Increased susceptibility to viral, fungal and bacterial infections.
  • Hair loss.
  • Nausea and vomiting.
  • Diarrhoea.
  • Loss of appetite.
  • Mouth ulceration.
  • Inflammation of the Oesophagus.
  • Skin rashes.
  • Anaemia.

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    Uncommon side effects of Imuran:

  • Hepatitis.
  • Severe anaemia.
  • Pancreatitis.Allergic reactions such as:
  • Fevers.
  • Rigors.
  • Muscle and joint aches.
  • Rash.
  • Cough.
  • Shortness of breath.
  • Low blood pressure.
  • Abnormal liver function.
  • Abnormal heart rhythm.
  • Kidney dysfunction.
  • Increased risk of skin cancers and certain other types of cancer.

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    Diseases treated by Imuran:

    Treatments associated with Imuran:


    For further information talk to your doctor.


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    Article Dates:

    calendar icon Created: 22/7/2003 calendar icon Modified: 24/5/2006

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