Taxotere

Drugs

Generic Name: Docetaxel
Product Name: Taxotere

Indication of Taxotere
Action of Taxotere
Dose Advice of Taxotere
Schedule of Taxotere
Common side effects of Taxotere
Uncommon side effects of Taxotere
Reference

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Indication of Taxotere:

Taxotere is used in the treatment of advanced cancers where other chemotherapy regimens have failed. It is used for:

treatment locally advanced or metastatic breast cancer in combination with capecitabine after the failure of anthracycline chemotherapy
adjuvant treatment of node positive breast cancer in combination with doxorubicin and cyclophosphamide
treatment in combination with trastuzumab of metastatic breast cancer where the tumour overexpresses HER2 and it has not previously received chemotherapy for metastases
treatment of metastatic or locally advanced non-small cell lung cancer including those that have failed platinum-based chemotherapy
treatment of metastatic carcinoma of the ovaries where first line or subsequent chemotherapy has failed
treatment of androgen independent (hormone refractory) prostate cancer

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Action of Taxotere:

Docetaxel is an antimetabolite agent known as a taxane. Taxanes are cytotoxic agents that work on a molecule called tubulin.

Tubulin is a protein important in the building of microtubules, which are vital in separation of chromosomes during cell division. Taxanes cause tubulin to be assembled into non-functional microtubules, which cells then can't disassemble. The non-functional microtubules cause the cells to become stranded halfway through cell division.

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