Drugs
Cisplatin Injection
Generic Name: Cisplatin
Product Name: Cisplatin Injection
- Indication of Cisplatin Injection
- Action of Cisplatin Injection
- Dose Advice of Cisplatin Injection
- Schedule of Cisplatin Injection
- Common side effects of Cisplatin Injection
- Uncommon side effects of Cisplatin Injection
Indication of Cisplatin Injection:
Cisplatin is used in the treatment of:- metastatic nonseminomatous germ cell cancer (type of testicular cancer)
- advanced ovarian carcinoma that has been unresponsive to other treatments
- advanced bladder carcinoma that has been unresponsive to other treatments
- squamous cell carcinoma of the head and neck that has been unresponsive to other treatments
For more health information on Cisplatin Injection visit your local doctor.
Action of Cisplatin Injection:
Cisplatin is a platinum compound that works as an antineoplastic agent. It works by producing links within and between DNA strands, which modifies the structure of DNA and prevents the production of new DNA. Production of proteins and RNA (vital for cell replication) are also inhibited to a lesser extent. Inhibition of production of these components leads to prevention of cell division and eventual cell death. Cisplatin is a non cell-cycle specific antineoplastic agent.Dose Advice of Cisplatin Injection:
Single agent therapy- 50-100mg/m2 as a single intravenous infusion over 6-8 hours every 3-4 weeks; or
- slow intravenous infusion of 15-20mg/m2 daily for 5 days, every 3-4 weeks
- dosages should be reduced in patients with depressed bone marrow function
Cisplatin can be used in combination with the following agents:
- testicular cancer: vinblastine, bleomycin, actinomycin D
- ovarian cancer: cyclophosphamide, doxorubicin, hexamethylmelamine, 5-fluorouracil
- cancers of head and neck: bleomycin, methotrexate
Retreatment with Cisplatin cannot begin until the following criteria have been met:
- serum creatinine below 140micromol/L
- plasma urea below 9mmol/L
- platelet count is greater than 100,000/mm3
- leucocyte count is greater than 4,000/mm3
- ensure adequate hydration prior to, during and after therapy
- required dose should be added to one litre of normal saline and infused over the required time
- pregnant staff should not handle Cisplatin
Schedule of Cisplatin Injection:
S4Common side effects of Cisplatin Injection:
- severe acute and delayed nausea and vomiting (sometimes so severe than dosage reduction or temporary cessation is required)
- kidney toxicity
- bone marrow suppression (with decreased numbers of platelets and white cells)
- mild hair loss
- tinnitus with or without hearing loss
- muscle irritability
- cramps
- unusual muscle contractions
- tremor
- tetany
The following neurological symptoms may occur and require cessation of treatment:
- peripheral neuropathies (damage to nerves of hands and feet)
- muscle weakness syndrome
- seizures
Uncommon side effects of Cisplatin Injection:
Decreased plasma phosphate and sodium occur less commonly. Other uncommon effects include:- change in liver enzymes
- hiccups
- blurred vision
- altered colour perception
Diseases treated by Cisplatin Injection:
Treatments associated with Cisplatin Injection:
- Platinum Therapy
(Platinum Therapy) - Platinum Therapy
(Platinum Therapy) - Platinum Therapy
(Platinum Therapy) - Platinum Therapy
(Platinum Therapy)
Regimens that include Cisplatin Injection:
- 5-Fluorouracil + Cisplatin
- CAF (Cyclophosphamide + Doxorubicin + Fluorouracil)
- CAP (Cyclophosphamide + Doxorubicin + Cisplatin)
- Cisplatin
- Cisplatin + Cyclophosphamide
- Cisplatin + Docetaxel
- Cisplatin + Epirubicin
- Cisplatin + Paclitaxel
- Cisplatin + Pemetrexed
- Cisplatin + Vinorelbine
- CMV (Cisplatin + Methotrexate + Vinblastine)
- DICE (Dexamethasone + Ifosfamide + Cisplatin + Etoposide)
- ECF (Epirubicin + Cisplatin + 5-Fluorouracil)
- EP (Etoposide + Cisplatin)
- Gemcitabine + Cisplatin
- MIC (Mitomycin + Ifosfamide + Cisplatin)
- MVAC (Methotrexate + Vinblastine + Doxorubicin + Cisplatin)
- TIP (Paclitaxel + Ifosfamide + Cisplatin)
For further information talk to your doctor.
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