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Drugs

Endep

Generic Name: Amitriptyline hydrochloride
Product Name: Endep

Indication of Endep:

Endep is used for:

  • Major depression.
  • Bed-wetting, urge incontinence.
  • Adjunct in pain management.


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    Action of Endep:

    Tricyclic antidepressants (TCA's) exert their effects by inhibiting the re-uptake of noradrenaline and serotonin into presynaptic terminals.

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    Dose Advice of Endep:

    Depression in adults:
  • 25-75mg daily, increasing by 25-50mg every 2-3 days to 75-150mg daily. Maximum 300mg daily.

    • Urinary urge incontinence:
  • 10-25mg 1-3 times daily.

    • Nocturnal enuresis in children:
  • Child 7-10 years- 10-20mg 30-60 minutes before bedtime; maximum period of treatment is 3 months.
  • Child older than 10 years- 25-50mg 30-60 minutes before bedtime; maximum period of treatment is 3 months.
  • Do not use for enuresis (Involuntary urination) in children under 7 years.


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    Schedule of Endep:

    S4

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    Common side effects of Endep:

    See uncommon side effects.

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    Uncommon side effects of Endep:

  • Sedation.
  • Dry mouth.
  • Blurred vision.
  • Constipation.
  • Weight gain.
  • Orthostatic hypotension.
  • Urinary hesitancy or retention.
  • Reduced gastrointestinal motility.
  • Anticholinergic delirium (particularly in the elderly and in Parkinson's Disease.
  • Impotence.
  • Loss of libido.
  • Other sexual adverse effects.
  • Tremor.
  • Dizziness.
  • Sweating.
  • Agitation.
  • Insomnia.


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    Diseases treated by Endep:


    For further information talk to your doctor.


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    Article Dates:

    calendar icon Created: 22/7/2003

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