Methotrexate (high dose)
Used For:
High dose Methotrexate is an investigational treatment that has been used in the treatment of:
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- Acute Lymphoblastic Leukaemia
- Cancer of the larynx (Laryngeal cancer, Squamous Cell Carcinoma of the Larynx)
- Hodgkin's Lymphoma
- Lung Cancer (Large Cell Carcinoma of the Lung)
- Lung Cancer (Squamous Cell Carcinoma of the Lung)
- Lymphoma of the Brain
- Non-Hodgkin's Lymphoma
- Oral Cancer (Squamous Cell Carcinoma of the Floor of the Mouth)
- Osteosarcoma (Osteogenic sarcoma)
- Pharynx Cancer (Squamous Cell Carcinoma of the Pharynx)
- Small Cell Lung Cancer (Carcinoma of the Lung)
- Spinal Cord Cancer (Lymphoma of the Spinal Cord)
- Throat cancer (Squamous Cell Carcinoma of the Tonsil)
- Tongue Cancer (Squamous Cell Carcinoma of the Tongue)
Overview:
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High dose Methotrexate is an investigational treatment. It is very hazardous and must always be followed by leucovorin (calcium folinate) rescue. Methotrexate is an antimetabolite agent that interferes with the replication of rapidly dividing cells (including cancer cells) by preventing the conversion of folic acid to folinic acid, a building block for new DNA. Methotrexate aims to reduce tumour size and prolong life.  |
Constituents:
Article Dates:
| Created: 12/5/2006 | Modified: 6/2/2007 |
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